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1998

First Puberty Blocker Prescribed for Gender Dysphoria

Health International Trans

Clinicians at the VU Medical Center in Amsterdam prescribed the GnRH agonist triptorelin to a young patient experiencing gender dysphoria, marking the first known clinical use of puberty blockers for this purpose. The pioneering case, documented by Peggy Cohen-Kettenis and Stephanie van Goozen, laid the groundwork for what would become the influential Dutch Protocol for treating adolescent gender dysphoria.

Impact & Significance

Established a new medical approach to adolescent gender dysphoria that would be adopted by clinics worldwide over the following two decades, fundamentally changing the landscape of trans youth healthcare.

Reference Record

Date
1998
Era
1990-1999
Sources
2

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